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Genetic architecture of artemisinin-resistant Plasmodium falciparum

December 23, 2016 by cemtrod0

We report a large multicenter genome-wide association study of Plasmodium falciparum
resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast
Asia, we identified at least 20 mutations in kelch13 (PF3D7_1343700) affecting the encoded
propeller and BTB/POZ domains, which were associated with a slow parasite clearance rate
after treatment with artemisinin derivatives. Nonsynonymous polymorphisms in fd
(ferredoxin), arps10 (apicoplast ribosomal protein S10), mdr2 (multidrug resistance

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Malaria remains a major public health problem in Africa and particularly in Nigeria. Focused research for development of new tools and providing evidence for appropriate interventions remain critical to its control. Malaria research in Nigeria had over the years been conducted mostly in Southern part of the country with the main capacities limited to just 2-3 Institutions.

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